Involvement of Na+, K+-ATPase and its inhibitors in HuR-mediated cytokine mRNA stabilization in lung epithelial cells

@article{Feng2010InvolvementON,
  title={Involvement of Na+, K+-ATPase and its inhibitors in HuR-mediated cytokine mRNA stabilization in lung epithelial cells},
  author={Su Ying Feng and Wei Chen and Dan Cao and Jinjun Bian and Fang-Yuan Gong and Wei Cheng and Shun Cheng and Qiang Xu and Zichun Hua and Wu Yin},
  journal={Cellular and Molecular Life Sciences},
  year={2010},
  volume={68},
  pages={109-124}
}
Increasing evidence demonstrates that Na+, K+-ATPase plays an important role in pulmonary inflammation, but the mechanism remains largely unknown. In this study, we used cardiotonic steroids as Na+, K+-ATPase inhibitors to explore the possible involvement of Na+, K+-ATPase in pulmonary epithelial inflammation. The results demonstrated that mice after ouabain inhalation developed cyclooxygenase-2-dependent acute lung inflammation. The in vitro experiments further confirmed that Na+, K+-ATPase… CONTINUE READING
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