Involvement of NOX1/NADPH oxidase in morphine-induced analgesia and tolerance.


The involvement of reactive oxygen species (ROS) in morphine-induced analgesia and tolerance has been suggested, yet how and where ROS take part in these processes remains largely unknown. Here, we report a novel role for the superoxide-generating enzyme NOX1/NADPH oxidase in the regulation of analgesia and acute analgesic tolerance. In mice lacking Nox1… (More)
DOI: 10.1523/JNEUROSCI.4136-11.2011

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