Involvement of NOX1/NADPH oxidase in morphine-induced analgesia and tolerance.

Abstract

The involvement of reactive oxygen species (ROS) in morphine-induced analgesia and tolerance has been suggested, yet how and where ROS take part in these processes remains largely unknown. Here, we report a novel role for the superoxide-generating enzyme NOX1/NADPH oxidase in the regulation of analgesia and acute analgesic tolerance. In mice lacking Nox1… (More)
DOI: 10.1523/JNEUROSCI.4136-11.2011

9 Figures and Tables

Topics

  • Presentations referencing similar topics