Involvement of NO-cGMP pathway in anti-anxiety effect of aminoguanidine in stressed mice.

  title={Involvement of NO-cGMP pathway in anti-anxiety effect of aminoguanidine in stressed mice.},
  author={Neeraj Gilhotra and Dinesh Dhingra},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  volume={33 8},
In the present study, effect of aminoguanidine (12.5, 25 and 50mg/kg, i.p.), a selective inhibitor of inducible nitric oxide synthase, was evaluated for its anti-anxiety activity in stressed mice employing elevated plus maze, open field test, light/dark test and social interaction test. Restraint stress induced by immobilizing for 6h enhanced an anxiety-like behavior and increased plasma nitrite levels in mice. Only the highest dose (50mg/kg) employed of aminoguanidine attenuated the stress… CONTINUE READING
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