Involvement of NMDA and AMPA/KA receptors in the nucleus accumbens core in instrumental learning guided by reward‐predictive cues

@article{Giertler2005InvolvementON,
  title={Involvement of NMDA and AMPA/KA receptors in the nucleus accumbens core in instrumental learning guided by reward‐predictive cues},
  author={Christian Giertler and Ines Bohn and Wolfgang Hauber},
  journal={European Journal of Neuroscience},
  year={2005},
  volume={21}
}
The use of reward‐predictive cues to guide behavior critically involves the nucleus accumbens. However, little is known regarding the role of ionotropic glutamate receptors in the core subregion of the nucleus accumbens (AcbC) in instrumental learning guided by reward‐predictive cues. Here we examined the effects of an intra‐AcbC blockade of NMDA and AMPA/KA receptors on the acquisition of an instrumental response in a reaction time (RT) task in rats. In this task, discriminative cues signaled… 

Intact discrimination reversal learning but slowed responding to reward-predictive cues after dopamine D1 and D2 receptor blockade in the nucleus accumbens of rats

In a visual discrimination task, D1 and D2 receptor-mediated signals in the AcbC seem to be unnecessary in updating the reward-predictive significance of cues, rather, they serve to activate instrumental behaviour.

NMDA and muscarinic receptors of the nucleus accumbens have differential effects on taste memory formation.

The results suggest that muscarinic receptors seem to be necessary for processing taste stimuli for either safe or aversive taste memory, whereas NMDA receptors are only involved in the aversive Taste memory trace formation.

Modulation of Behavior by Expected Reward Magnitude Depends on Dopamine in the Dorsomedial Striatum

It is suggested that dopamine signaling in the pDMS contributes to a process through which reward-directed responses become guided by cues associated with distinct reward magnitudes, and does not subserve stimulus discrimination per se and stimulus-response learning.

Lesions of the orbitofrontal cortex do not affect the reinforcement omission effect in rats

The findings confirm previous studies that showed that the ROE is not related to the facilitation of behavior induced by nonreinforcement.

Neurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodents.

The roles of several neurotransmitters and neuropeptides in the functioning of the NAc are discussed, including dopamine, glutamate, gamma-aminobutyric acid, acetylcholine, serotonin, dynorphin, enkephaline, brain-derived neurotrophic factor, cAMP response element-binding protein (CREB), melanin-concentrating hormone (MCH) and cocaine- and amphetamine-regulated transcript (CART).

Effects of lesions of the nucleus accumbens core on choice between small certain rewards and large uncertain rewards in rats

The view that the AcbC contributes to action selection by promoting the choice of uncertain, as well as delayed, reinforcement is supported.

Neurobiology of expectancy effects and omission of reinforcement on behavior

The studies reviewed here indicate that amygdala is involved in modulation of reinforcement omission effects and the connection of amygdala subareas to cortical and subcortical structures may be involved in this modulation since they also are linked to processes related to reward and expectancy.

References

SHOWING 1-10 OF 63 REFERENCES

NMDA, But Not Dopamine D2, Receptors in the Rat Nucleus Accumbens Are Involved in Guidance of Instrumental Behavior by Stimuli Predicting Reward Magnitude

The data reveal that in well trained animals stimulation of intra-NAc NMDA, but not of dopamine D2, receptors, is critically involved in guiding the speed of instrumental responses according to stimuli predictive of the upcoming reward magnitude.

The rat nucleus accumbens is involved in guiding of instrumental responses by stimuli predicting reward magnitude

The present study examined the involvement of N‐methyl‐d‐aspartate (NMDA), α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolpropionate/kainate (AMPA/KA) and dopamine receptors in the nucleus accumbens (ACB) in

Appetitive Instrumental Learning Requires Coincident Activation of NMDA and Dopamine D1 Receptors within the Medial Prefrontal Cortex

It is hypothesized that coincident detection of D1–NMDA receptor activation and its transcriptional consequences, within multiple sites of a distributed corticostriatal network, may represent a conserved molecular mechanism for instrumental learning.

NMDA receptors in the rat orbital prefrontal cortex are involved in guidance of instrumental behaviour under reversal conditions.

Novel evidence is provided for NMDA-receptor-dependent plasticity in the OPFC in reversal learning and latencies of correct responses were generally shortened, regardless of the response-associated reward magnitude.

Differential Involvement of NMDA, AMPA/Kainate, and Dopamine Receptors in the Nucleus Accumbens Core in the Acquisition and Performance of Pavlovian Approach Behavior

The present experiment investigated the effects of infusions of glutamatergic or dopaminergic receptor antagonists into the core of the nucleus accumbens on the acquisition and performance of Pavlovian discriminated approach to an appetitive conditioned stimulus.

Coincident Activation of NMDA and Dopamine D1Receptors within the Nucleus Accumbens Core Is Required for Appetitive Instrumental Learning

It is hypothesized that co-activation of NMDA and D1 receptors in the nucleus accumbens core is a key process for acquisition of appetitive instrumental learning and is supported by a number of cellular models.

Contrasting effects of dopamine and glutamate receptor antagonist injection in the nucleus accumbens suggest a neural mechanism underlying cue‐evoked goal‐directed behavior

It is shown in rats that DSs can reinstate food‐seeking behavior and a model for the functional role of NAc neurons in controlling behavioral responses to reward‐predictive stimuli is proposed.

Response-reinforcement learning is dependent on N-methyl-D-aspartate receptor activation in the nucleus accumbens core.

It is hypothesized that stimulation of NMDA receptors within the accumbens core is a key process through which motor responses become established in response to reinforcing stimuli and may also play a critical role in the motivational and addictive properties of drugs of abuse.

Early consolidation of instrumental learning requires protein synthesis in the nucleus accumbens

It is shown that the inhibition of protein synthesis within the NAc disrupts consolidation of an appetitive instrumental learning task (lever-pressing for food) in rats and shows that de novo protein synthesis is necessary for the consolidation, but not reconsolidation, of appetive instrumental memories.
...