Involvement of NMDA and AMPA/KA receptors in the nucleus accumbens core in instrumental learning guided by reward‐predictive cues

  title={Involvement of NMDA and AMPA/KA receptors in the nucleus accumbens core in instrumental learning guided by reward‐predictive cues},
  author={Christian Giertler and Ines Bohn and Wolfgang Hauber},
  journal={European Journal of Neuroscience},
The use of reward‐predictive cues to guide behavior critically involves the nucleus accumbens. However, little is known regarding the role of ionotropic glutamate receptors in the core subregion of the nucleus accumbens (AcbC) in instrumental learning guided by reward‐predictive cues. Here we examined the effects of an intra‐AcbC blockade of NMDA and AMPA/KA receptors on the acquisition of an instrumental response in a reaction time (RT) task in rats. In this task, discriminative cues signaled… 

Intact discrimination reversal learning but slowed responding to reward-predictive cues after dopamine D1 and D2 receptor blockade in the nucleus accumbens of rats

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NMDA and muscarinic receptors of the nucleus accumbens have differential effects on taste memory formation.

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Neurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodents.

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The view that the AcbC contributes to action selection by promoting the choice of uncertain, as well as delayed, reinforcement is supported.

Neurobiology of expectancy effects and omission of reinforcement on behavior

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NMDA, But Not Dopamine D2, Receptors in the Rat Nucleus Accumbens Are Involved in Guidance of Instrumental Behavior by Stimuli Predicting Reward Magnitude

The data reveal that in well trained animals stimulation of intra-NAc NMDA, but not of dopamine D2, receptors, is critically involved in guiding the speed of instrumental responses according to stimuli predictive of the upcoming reward magnitude.

The rat nucleus accumbens is involved in guiding of instrumental responses by stimuli predicting reward magnitude

The present study examined the involvement of N‐methyl‐d‐aspartate (NMDA), α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolpropionate/kainate (AMPA/KA) and dopamine receptors in the nucleus accumbens (ACB) in

Appetitive Instrumental Learning Requires Coincident Activation of NMDA and Dopamine D1 Receptors within the Medial Prefrontal Cortex

It is hypothesized that coincident detection of D1–NMDA receptor activation and its transcriptional consequences, within multiple sites of a distributed corticostriatal network, may represent a conserved molecular mechanism for instrumental learning.

NMDA receptors in the rat orbital prefrontal cortex are involved in guidance of instrumental behaviour under reversal conditions.

Novel evidence is provided for NMDA-receptor-dependent plasticity in the OPFC in reversal learning and latencies of correct responses were generally shortened, regardless of the response-associated reward magnitude.

Differential Involvement of NMDA, AMPA/Kainate, and Dopamine Receptors in the Nucleus Accumbens Core in the Acquisition and Performance of Pavlovian Approach Behavior

The present experiment investigated the effects of infusions of glutamatergic or dopaminergic receptor antagonists into the core of the nucleus accumbens on the acquisition and performance of Pavlovian discriminated approach to an appetitive conditioned stimulus.

Coincident Activation of NMDA and Dopamine D1Receptors within the Nucleus Accumbens Core Is Required for Appetitive Instrumental Learning

It is hypothesized that co-activation of NMDA and D1 receptors in the nucleus accumbens core is a key process for acquisition of appetitive instrumental learning and is supported by a number of cellular models.

Contrasting effects of dopamine and glutamate receptor antagonist injection in the nucleus accumbens suggest a neural mechanism underlying cue‐evoked goal‐directed behavior

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Response-reinforcement learning is dependent on N-methyl-D-aspartate receptor activation in the nucleus accumbens core.

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Early consolidation of instrumental learning requires protein synthesis in the nucleus accumbens

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