Involvement of NMDA and AMPA/KA receptors in the nucleus accumbens core in instrumental learning guided by reward‐predictive cues

@article{Giertler2005InvolvementON,
  title={Involvement of NMDA and AMPA/KA receptors in the nucleus accumbens core in instrumental learning guided by reward‐predictive cues},
  author={Christian Giertler and Ines Bohn and Wolfgang Hauber},
  journal={European Journal of Neuroscience},
  year={2005},
  volume={21}
}
The use of reward‐predictive cues to guide behavior critically involves the nucleus accumbens. However, little is known regarding the role of ionotropic glutamate receptors in the core subregion of the nucleus accumbens (AcbC) in instrumental learning guided by reward‐predictive cues. Here we examined the effects of an intra‐AcbC blockade of NMDA and AMPA/KA receptors on the acquisition of an instrumental response in a reaction time (RT) task in rats. In this task, discriminative cues signaled… Expand
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References

SHOWING 1-10 OF 65 REFERENCES
NMDA, But Not Dopamine D2, Receptors in the Rat Nucleus Accumbens Are Involved in Guidance of Instrumental Behavior by Stimuli Predicting Reward Magnitude
TLDR
The data reveal that in well trained animals stimulation of intra-NAc NMDA, but not of dopamine D2, receptors, is critically involved in guiding the speed of instrumental responses according to stimuli predictive of the upcoming reward magnitude. Expand
The rat nucleus accumbens is involved in guiding of instrumental responses by stimuli predicting reward magnitude
The present study examined the involvement of N‐methyl‐d‐aspartate (NMDA), α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolpropionate/kainate (AMPA/KA) and dopamine receptors in the nucleus accumbens (ACB) inExpand
Appetitive Instrumental Learning Requires Coincident Activation of NMDA and Dopamine D1 Receptors within the Medial Prefrontal Cortex
TLDR
It is hypothesized that coincident detection of D1–NMDA receptor activation and its transcriptional consequences, within multiple sites of a distributed corticostriatal network, may represent a conserved molecular mechanism for instrumental learning. Expand
NMDA receptors in the rat orbital prefrontal cortex are involved in guidance of instrumental behaviour under reversal conditions.
TLDR
Novel evidence is provided for NMDA-receptor-dependent plasticity in the OPFC in reversal learning and latencies of correct responses were generally shortened, regardless of the response-associated reward magnitude. Expand
Differential Involvement of NMDA, AMPA/Kainate, and Dopamine Receptors in the Nucleus Accumbens Core in the Acquisition and Performance of Pavlovian Approach Behavior
TLDR
The present experiment investigated the effects of infusions of glutamatergic or dopaminergic receptor antagonists into the core of the nucleus accumbens on the acquisition and performance of Pavlovian discriminated approach to an appetitive conditioned stimulus. Expand
Coincident Activation of NMDA and Dopamine D1Receptors within the Nucleus Accumbens Core Is Required for Appetitive Instrumental Learning
TLDR
It is hypothesized that co-activation of NMDA and D1 receptors in the nucleus accumbens core is a key process for acquisition of appetitive instrumental learning and is supported by a number of cellular models. Expand
Contrasting effects of dopamine and glutamate receptor antagonist injection in the nucleus accumbens suggest a neural mechanism underlying cue‐evoked goal‐directed behavior
TLDR
It is shown in rats that DSs can reinstate food‐seeking behavior and a model for the functional role of NAc neurons in controlling behavioral responses to reward‐predictive stimuli is proposed. Expand
Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior
TLDR
Results indicate that NMDA and AMPA receptor-mediated glutamate transmission in the core and shell are dissociably involved in cocaine-seeking behavior controlled in part by drug-associated cues. Expand
Response-reinforcement learning is dependent on N-methyl-D-aspartate receptor activation in the nucleus accumbens core.
TLDR
It is hypothesized that stimulation of NMDA receptors within the accumbens core is a key process through which motor responses become established in response to reinforcing stimuli and may also play a critical role in the motivational and addictive properties of drugs of abuse. Expand
Early consolidation of instrumental learning requires protein synthesis in the nucleus accumbens
TLDR
It is shown that the inhibition of protein synthesis within the NAc disrupts consolidation of an appetitive instrumental learning task (lever-pressing for food) in rats and shows that de novo protein synthesis is necessary for the consolidation, but not reconsolidation, of appetive instrumental memories. Expand
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