Involvement of NMDA and AMPA/KA receptors in the nucleus accumbens core in instrumental learning guided by reward-predictive cues.

@article{Giertler2005InvolvementON,
  title={Involvement of NMDA and AMPA/KA receptors in the nucleus accumbens core in instrumental learning guided by reward-predictive cues.},
  author={Christian Giertler and Ines Bohn and Wolfgang Hauber},
  journal={The European journal of neuroscience},
  year={2005},
  volume={21 6},
  pages={1689-702}
}
The use of reward-predictive cues to guide behavior critically involves the nucleus accumbens. However, little is known regarding the role of ionotropic glutamate receptors in the core subregion of the nucleus accumbens (AcbC) in instrumental learning guided by reward-predictive cues. Here we examined the effects of an intra-AcbC blockade of NMDA and AMPA/KA receptors on the acquisition of an instrumental response in a reaction time (RT) task in rats. In this task, discriminative cues signaled… CONTINUE READING

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