Involvement of NF-kappaB in the regulation of S100A6 gene expression in human hepatoblastoma cell line HepG2.

@article{Joo2003InvolvementON,
  title={Involvement of NF-kappaB in the regulation of S100A6 gene expression in human hepatoblastoma cell line HepG2.},
  author={Joung Hyuck Joo and Jae Wha Kim and Younghee Lee and Sun Young Yoon and Joo Heon Kim and S W Paik and In Seong Choe},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={307 2},
  pages={274-80}
}
S100A6 (calcyclin) is an acidic calcium binding protein with two EF-hand motifs and overexpressed in several tumors including intrahepatic carcinoma. TNFalpha, a strong NF-kappaB activator required for hepatocyte proliferation during liver regeneration, triggered the expression of S100A6 mRNA in human hepatoblastoma cell line HepG2. Transient expression of NF-kappaB (p65) increased S100A6 promoter activity and expression of inhibitor of NF-kappaB (IkappaBalpha) decreased TNFalpha-induced S100A6… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Chemoprevention of liver cancer by plant polyphenols.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2012
View 3 Excerpts

Emerging avenues linking inflammation and cancer.

Free radical biology & medicine • 2012
View 1 Excerpt

NF-κB in liver cancer: the plot thickens.

Current topics in microbiology and immunology • 2011
View 1 Excerpt

Similar Papers

Loading similar papers…