Involvement of NF-κBIZ and related cytokines in age-associated renal fibrosis

@inproceedings{Chung2017InvolvementON,
  title={Involvement of NF-κBIZ and related cytokines in age-associated renal fibrosis},
  author={Ki Wung Chung and Hyeong Oh Jeong and Bonggi Lee and Daeui Park and Dae Hyun Kim and Yeun Ja Choi and Eun Kyeong Lee and Kyung Mok Kim and June Whoun Park and Byung Pal Yu and Hae Young Chung},
  booktitle={Oncotarget},
  year={2017}
}
  • Ki Wung Chung, Hyeong Oh Jeong, +8 authors Hae Young Chung
  • Published in Oncotarget 2017
  • Medicine
  • Chronic inflammation is a major contributor to age-related nephropathic changes, including renal fibrosis. In this study, various experimental paradigms were designed to delineate the role played by NF-κBIZ (also known as IκBζ) in age-associated renal fibrosis. Analyses based on RNA-sequencing findings obtained by next generation sequencing (NGS) revealed the upregulations of NF-κBIZ and of IL-6 and MCP-1 (both known to be regulated by NF-κBIZ) during aging. The up-regulation of NF-κBIZ in aged… CONTINUE READING

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