Involvement of NCAM in the effects of GDNF on the neurite outgrowth in the dopamine neurons.

@article{Cao2008InvolvementON,
  title={Involvement of NCAM in the effects of GDNF on the neurite outgrowth in the dopamine neurons.},
  author={Jun-ping Cao and Hongjun Wang and Jing-kao Yu and Hua Yang and Cheng-hua Xiao and Dian-Shuai Gao},
  journal={Neuroscience research},
  year={2008},
  volume={61 4},
  pages={390-7}
}
Glial cell line-derived neurotrophic factor (GDNF) exerts its biological effects via a multi-component receptor system including the ligand binding receptor--GDNF family receptor-alpha1 (GFRalpha1) and the signaling receptor--RET tyrosine kinase. Recently, the neural cell adhesion molecule (NCAM) has been identified as an alternative signaling receptor for GDNF. The purpose of this study was to investigate whether NCAM could mediate the protective effect of GDNF on injured dopamine (DA) neurons… CONTINUE READING