Involvement of N-methyl-D-aspartate-type glutamate receptor epsilon1 and epsilon4 subunits in tonic inflammatory pain and neuropathic pain.

@article{Hizue2005InvolvementON,
  title={Involvement of N-methyl-D-aspartate-type glutamate receptor epsilon1 and epsilon4 subunits in tonic inflammatory pain and neuropathic pain.},
  author={Masanori Hizue and Chang-Hong Pang and Masayuki Yokoyama},
  journal={Neuroreport},
  year={2005},
  volume={16 15},
  pages={1667-70}
}
N-methyl-D-aspartate receptors play an important role in nociceptive transmissions in various types of pain. In this study, we investigated the pain-related response in mice lacking the N-methyl-D-aspartate-type glutamate receptor epsilon1 or epsilon4 subunit in the formalin test and in the partial sciatic nerve ligation-induced neuropathic pain model. The second tonic inflammatory phase response in the formalin test was significantly reduced in glutamate receptor epsilon1 knockout epsilon1… CONTINUE READING

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