Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human.

@article{Choi2009InvolvementOM,
  title={Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human.},
  author={M-K Choi and H Kim and Y Han and I S Song and C-K Shim},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2009},
  volume={39 2},
  pages={171-81}
}
1. The purpose of this study was to investigate the involvement of rat Mrp2 and human MRP2 in benzylpenicillin transport using canalicular liver plasma membrane (cLPM) vesicles isolated from Sprague-Dawley or Easai hyperbilirubinemic (EHBR) rats, and MDCKII cells overexpressing MRP2. 2. The adenosine triphosphate (ATP)-dependent uptake of benzylpenicillin and oestradiol-17beta-D-glucuronide (E(2)17betaG), a representative substrate for Mrp2, into EHBR-cLPM vesicles was decreased relative to… CONTINUE READING