Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.

@article{Nicke2005InvolvementOM,
  title={Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.},
  author={Barbara Nicke and Julie Bastien and Sophia J Khanna and Patricia H. Warne and Victoria Cowling and Simon J Cook and Gordon G Peters and Oona Delpuech and Almut Schulze and Katrien Berns and Jasper Mullenders and Roderick Leonardus Beijersbergen and Ren{\'e} Bernards and Trivadi Sundaram Ganesan and Julian Downward and David C. Hancock},
  journal={Molecular cell},
  year={2005},
  volume={20 5},
  pages={673-85}
}
The ability of activated Ras to induce growth arrest of human ovarian surface epithelial (HOSE) cells via induction of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) has been used to screen for Ras pathway signaling components using a library of RNA interference (RNAi) vectors targeting the kinome. Two known Ras-regulated kinases were identified, phosphoinositide 3-kinase p110alpha and ribosomal protein S6 kinase p70(S6K1), plus the MAP kinase kinase kinase kinase MINK, which had not… CONTINUE READING

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