Involvement of MAPK, Akt/GSK-3β and AMPK/mTOR signaling pathways in protection of remote glial cells from axotomy-induced necrosis and apoptosis in the isolated crayfish stretch receptor.

@article{Berezhnaya2017InvolvementOM,
  title={Involvement of MAPK, Akt/GSK-3β and AMPK/mTOR signaling pathways in protection of remote glial cells from axotomy-induced necrosis and apoptosis in the isolated crayfish stretch receptor.},
  author={Elena Berezhnaya and Mikhail Y Bibov and Maxim A. Komandirov and Maria Neginskaya and Mikhail V. Rudkovskii and Anatoly B. Uzdensky},
  journal={Molecular and cellular neurosciences},
  year={2017},
  volume={83},
  pages={
          1-5
        }
}
Severe mechanical nerve injury such as axotomy can lead to neuron degeneration and death of surrounding glial cells. We showed that axotomy not only mechanically injures glial cells at the cutting location, but also induces necrosis or apoptosis of satellite glial cells remote from the transection site. Therefore, axon integrity is necessary for survival of… CONTINUE READING