Involvement of MAP-kinase cascades in regulation of sodium-butyrate-induced premature senescence

@article{Kochetkova2013InvolvementOM,
  title={Involvement of MAP-kinase cascades in regulation of sodium-butyrate-induced premature senescence},
  author={E. Kochetkova and Tatiana V Bykova and Svetlana G Zubova and Tatyana V. Pospelova},
  journal={Cell and Tissue Biology},
  year={2013},
  volume={7},
  pages={126-135}
}
We have studied the role of the stress kinases p38 and JNK1,2 in premature senescence induced by sodium butyrate (NaBut), a histone deacetylase inhibitor, in mouse embryonic fibroblasts transformed by E1A+cHa-Ras oncogenes. It was found that transformants from p38 knockout cells are able to implement NaBut-induced senescence exhibited by cell cycle arrest, inhibition of proliferation, hypertrophic changes associated with mTORC1 activation and SA-β-galactosidase activity. In jnk1,2 knockouts… CONTINUE READING
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