Involvement of Local Lamellipodia in Endothelial Barrier Function

  title={Involvement of Local Lamellipodia in Endothelial Barrier Function},
  author={Jerome W Breslin and Xun E. Zhang and Rebecca A. Worthylake and Flavia M Souza-Smith},
  booktitle={PloS one},
Recently we observed that endothelial cells cultured in tightly confluent monolayers display frequent local lamellipodia, and that thrombin, an agent that increases endothelial permeability, reduces lamellipodia protrusions. This led us to test the hypothesis that local lamellipodia contribute to endothelial barrier function. Movements of subcellular structures containing GFP-actin or VE-cadherin-GFP expressed in endothelial cells were recorded using time-lapse microscopy. Transendothelial… CONTINUE READING


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Microcirculatory Exchange Function

  • DuránWN, FA Sanchez, JW Breslin
  • Handbook of Physiology: Microcirculation. 2nd ed
  • 2008
Highly Influential
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