Involvement of KSRP in the post-transcriptional regulation of human iNOS expression–complex interplay of KSRP with TTP and HuR

@article{Linker2005InvolvementOK,
  title={Involvement of KSRP in the post-transcriptional regulation of human iNOS expression–complex interplay of KSRP with TTP and HuR},
  author={Katrin Linker and Andrea Pautz and Marcel Fechir and Thomas Hubrich and J. Greeve and Hartmut Kleinert},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={4813 - 4827}
}
We purified the KH-type splicing regulatory protein (KSRP) as a protein interacting with the 3'-untranslated region (3'-UTR) of the human inducible nitric oxide (iNOS) mRNA. Immunodepletion of KSRP enhanced iNOS 3'-UTR RNA stability in in vitro-degradation assays. In DLD-1 cells overexpressing KSRP cytokine-induced iNOS expression was markedly reduced. In accordance, downregulation of KSRP expression increases iNOS expression by stabilizing iNOS mRNA. Co-immunoprecipitations showed interaction… CONTINUE READING

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