Involvement of JNK in the regulation of autophagic cell death

@article{Shimizu2010InvolvementOJ,
  title={Involvement of JNK in the regulation of autophagic cell death},
  author={Shigeomi Shimizu and Akio Konishi and Yuya Nishida and Takeshi Mizuta and Hiroshi Nishina and Akitsugu Yamamoto and Yoshihide Tsujimoto},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={2070-2082}
}
Programmed cell death is a crucial process in the normal development and physiology of metazoans, and it can be divided into several categories that include type I death (apoptosis) and type II death (autophagic cell death). The Bcl-2 family proteins are well-characterized regulators of apoptosis, among which multidomain pro-apoptotic members (such as Bax and Bak) function as a mitochondrial gateway at which various apoptotic signals converge. Although embryonic fibroblasts from Bax/Bak double… CONTINUE READING
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