• DOI:10.1016/S0091-3057(98)00168-3
Corpus ID: 37434490

Involvement of Intracellular Calcium in Morphine Tolerance in Mice

@article{Smith1999InvolvementOI,
  title={Involvement of Intracellular Calcium in Morphine Tolerance in Mice},
  author={F. L. Smith and D. Dombrowski and W. Dewey},
  journal={Pharmacology Biochemistry and Behavior},
  year={1999},
  volume={62},
  pages={381-388}
}

• F. L. Smith, D. Dombrowski, W. Dewey
• Published 1999
• Medicine, Chemistry
• Pharmacology Biochemistry and Behavior

Opioid analgesic tolerance is associated with a disruption in Ca++ homeostasis. Drugs reducing Ca++ influx can prevent and reverse tolerance. The hypothesis was tested that both Ca++ influx and mobilization from intracellular pools maintains the expression of morphine tolerance. Ca++ modulating drugs were injected ICV at doses not affecting morphine's potency in placebo pellet-implanted mice, in order to determine whether tolerance would be reversed in morphine pellet-implanted mice. The Ca… Expand