Involvement of Intracellular Calcium in Morphine Tolerance in Mice

@article{Smith1999InvolvementOI,
  title={Involvement of Intracellular Calcium in Morphine Tolerance in Mice},
  author={F. Smith and D. Dombrowski and W. Dewey},
  journal={Pharmacology Biochemistry and Behavior},
  year={1999},
  volume={62},
  pages={381-388}
}
  • F. Smith, D. Dombrowski, W. Dewey
  • Published 1999
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
  • Opioid analgesic tolerance is associated with a disruption in Ca++ homeostasis. Drugs reducing Ca++ influx can prevent and reverse tolerance. The hypothesis was tested that both Ca++ influx and mobilization from intracellular pools maintains the expression of morphine tolerance. Ca++ modulating drugs were injected ICV at doses not affecting morphine's potency in placebo pellet-implanted mice, in order to determine whether tolerance would be reversed in morphine pellet-implanted mice. The Ca… CONTINUE READING
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