Involvement of Intracellular Calcium in Morphine Tolerance in Mice

@article{Smith1999InvolvementOI,
  title={Involvement of Intracellular Calcium in Morphine Tolerance in Mice},
  author={F. L. Smith and D. Dombrowski and W. Dewey},
  journal={Pharmacology Biochemistry and Behavior},
  year={1999},
  volume={62},
  pages={381-388}
}
Opioid analgesic tolerance is associated with a disruption in Ca++ homeostasis. Drugs reducing Ca++ influx can prevent and reverse tolerance. The hypothesis was tested that both Ca++ influx and mobilization from intracellular pools maintains the expression of morphine tolerance. Ca++ modulating drugs were injected ICV at doses not affecting morphine's potency in placebo pellet-implanted mice, in order to determine whether tolerance would be reversed in morphine pellet-implanted mice. The Ca… Expand
Involvement of phospholipid signal transduction pathways in morphine tolerance in mice
Role of CD38, a Cyclic ADP-Ribosylcyclase, in Morphine Antinociception and Tolerance
...
1
2
3
4
...

References

SHOWING 1-10 OF 50 REFERENCES
Calcium modulation of morphine analgesia: role of calcium channels and intracellular pool calcium.
Effects of divalent cations, cation chelators and an ionophore on morphine analgesia and tolerance.
  • R. Harris, H. Loh, E. Way
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1975
Calcium‐induced calcium release in rat sensory neurons.
...
1
2
3
4
5
...