Involvement of Intracellular Calcium in Morphine Tolerance in Mice
@article{Smith1999InvolvementOI, title={Involvement of Intracellular Calcium in Morphine Tolerance in Mice}, author={Forrest L. Smith and Daniel S. Dombrowski and William L. Dewey}, journal={Pharmacology Biochemistry and Behavior}, year={1999}, volume={62}, pages={381-388} }
36 Citations
Involvement of phospholipid signal transduction pathways in morphine tolerance in mice
- BiologyBritish journal of pharmacology
- 1999
Evidence is accumulating that opioid tolerance disrupts the homeostatic balance of several important signal transduction pathways and a potential role for inositol 1,4,5‐trisphosphate (IP3) and protein kinase C (PKC) in tolerance is suggested.
Blocking the R‐type (Cav2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance
- BiologyThe European journal of neuroscience
- 2004
The inhibition of R‐type Ca2+ current could lead to high‐efficiency opioid therapy without tolerance, as it is speculated that voltage‐dependent Ca3+ channels play a key role in morphine analgesia and tolerance.
L-type Ca(2+) channel blockers inhibit the development but not the expression of sensitization to morphine in mice.
- Biology, PsychologyEuropean journal of pharmacology
- 2003
Role of CD38, a Cyclic ADP-Ribosylcyclase, in Morphine Antinociception and Tolerance
- BiologyJournal of Pharmacology and Experimental Therapeutics
- 2010
Results indicate that cADRP–ryanodine receptor Ca2+ signaling associated with CD38 plays an important role in morphine tolerance.
Fluoxetine increases analgesic effects of morphine, prevents development of morphine tolerance and dependence through the modulation of L-type calcium channels expression in mice
- Biology, MedicineBehavioural Brain Research
- 2019
The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA
- BiologyBrain Research
- 2003
Role of kappa and delta opioid receptors in mediating morphine-induced antinociception in morphine-tolerant infant rats
- Biology, PsychologyBrain Research
- 2007
PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice.
- BiologyPharmacological research
- 2006
COMPARISON OF ACUTE AND CHRONIC EFFECTS OF NIFEDIPINE ON NALOXONE-PRECIPITATED MORPHINE WITHDRAWAL IN MICE
- Biology, Chemistry
- 2003
The results suggest that alterations in dihydropyridine-sensitive calcium channels may be involved in the adaptations that occur on chronic treatment with morphine, and that separate mechanisms areinvolved in the development of tolerance and dependence.
Involvement of hypothalamic pituitary adrenal axis on the analgesic cross-tolerance between morphine and nifedipine
- Biology, MedicinePharmacology Biochemistry and Behavior
- 2007
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