Involvement of IbeA in meningitic Escherichia coli K1-induced polymorphonuclear leukocyte transmigration across brain endothelial cells.

@article{Che2011InvolvementOI,
  title={Involvement of IbeA in meningitic Escherichia coli K1-induced polymorphonuclear leukocyte transmigration across brain endothelial cells.},
  author={Xiaojuan Che and Feng Chi and Lin Lin Wang and Timothy D Jong and Chun-hua Wu and Xiaoning Wang and Sheng-He Huang},
  journal={Brain pathology},
  year={2011},
  volume={21 4},
  pages={389-404}
}
Transmigration of neutrophil [polymorphonuclear neutrophil (PMN)] across the blood-brain barrier (BBB) is a critical event in the pathogenesis of bacterial meningitis. We have shown that IbeA is able to induce meningitic Escherichia coli invasion of brain microvascular endothelial cells (BMECs), which constitutes the BBB. In this report, we provide evidence that IbeA and its receptor, vimentin, play a key role in E. coli-induced PMN transmigration across BMEC. In vitro and in vivo studies… CONTINUE READING