Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia.

  title={Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia.},
  author={Keiko Ohsawa and Yoshinori Imai and Hiroko Kanazawa and Yo Sasaki and Shinichi Kohsaka},
  journal={Journal of cell science},
  volume={113 ( Pt 17)},
Ionized calcium binding adaptor molecule 1, Iba1, is an EF hand calcium binding protein whose expression is restricted to macrophages/microglia. In this study, Iba1 was shown to colocalize with F-actin in membrane ruffles induced by macrophage colony-stimulating factor and in phagocytic cups formed during zymosan phagocytosis. Expression of mutant Iba1 carrying either N- or C-terminal deletions or carrying a substitution in the calcium binding domain, suppressed the membrane ruffling and the… CONTINUE READING


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Publications referenced by this paper.
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Cloning and characterization of allograft inflammatory factor - 1 : a novel macrophage factor identified in rat cardiac allografts with chronic rejection

U. von Eitzen, R. Egensperger, +6 authors M. B. Graeber
J . Clin . Invest . • 1998

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