Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia.

@article{Ohsawa2000InvolvementOI,
  title={Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia.},
  author={Keiko Ohsawa and Yoshinori Imai and Hiroko Kanazawa and Yo Sasaki and Shinichi Kohsaka},
  journal={Journal of cell science},
  year={2000},
  volume={113 ( Pt 17)},
  pages={3073-84}
}
Ionized calcium binding adaptor molecule 1, Iba1, is an EF hand calcium binding protein whose expression is restricted to macrophages/microglia. In this study, Iba1 was shown to colocalize with F-actin in membrane ruffles induced by macrophage colony-stimulating factor and in phagocytic cups formed during zymosan phagocytosis. Expression of mutant Iba1 carrying either N- or C-terminal deletions or carrying a substitution in the calcium binding domain, suppressed the membrane ruffling and the… CONTINUE READING

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