Corpus ID: 21332522

Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia.

  title={Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia.},
  author={K. Ohsawa and Y. Imai and H. Kanazawa and Y. Sasaki and S. Kohsaka},
  journal={Journal of cell science},
  volume={113 ( Pt 17)},
  • K. Ohsawa, Y. Imai, +2 authors S. Kohsaka
  • Published 2000
  • Biology, Medicine
  • Journal of cell science
  • Ionized calcium binding adaptor molecule 1, Iba1, is an EF hand calcium binding protein whose expression is restricted to macrophages/microglia. In this study, Iba1 was shown to colocalize with F-actin in membrane ruffles induced by macrophage colony-stimulating factor and in phagocytic cups formed during zymosan phagocytosis. Expression of mutant Iba1 carrying either N- or C-terminal deletions or carrying a substitution in the calcium binding domain, suppressed the membrane ruffling and the… CONTINUE READING
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