Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages.

  title={Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages.},
  author={Kuniko Nakayama and Shu Okugawa and Shintaro Yanagimoto and Takatoshi Kitazawa and Kunihisa Tsukada and Miki Kawada and Satoshi Kensuke Kimura and Koichi Hirai and Yohtaroh Takagaki and Yasuo Ota},
  journal={The Journal of biological chemistry},
  volume={279 8},
The molecular mechanisms by which pathogen-associated molecular patterns recognized by TLR2, such as peptidoglycan (PGN), induce homotolerance are largely unknown. It was recently reported that IRAK-M negatively regulates TLR signaling. In this study, we elucidate the molecular mechanisms of tolerance induced by PGN, with a focus on the role of IRAK-M. We demonstrate that pretreatment of macrophage RAW264.7 cells with a high concentration (30 microg/ml) of PGN for 16 h effectively induces… CONTINUE READING