Involvement of IL-9 in Th17-Associated Inflammation and Angiogenesis of Psoriasis

@inproceedings{Singh2013InvolvementOI,
  title={Involvement of IL-9 in Th17-Associated Inflammation and Angiogenesis of Psoriasis},
  author={Tej Pratap Singh and Michael P Sch{\"o}n and Katrin Wallbrecht and Alexandra Gruber-Wackernagel and Xiao-Jing Wang and Peter Wolf},
  booktitle={PloS one},
  year={2013}
}
It is thought that a Th1/Th17-weighted immune response plays a predominant role in the pathogenesis of psoriasis. Our findings now indicate a link between IL-9, a Th2 and Th9 cytokine, and Th17 pathway in psoriasis. In K5.hTGF-β1 transgenic mice, exhibiting a psoriasis-like phenotype, we found increased IL-9R and IL-9 expression in the skin and intradermal IL-9 injection induced Th17-related inflammation. IL-9 also promoted angiogenesis and VEGF and CD31 overexpression in mice in vivo and… CONTINUE READING

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