Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction.

@article{Yin1993InvolvementOI,
  title={Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction.},
  author={Tie-yong Yin and Tetsuya Taga and Ming Li Tsang and Kiyoshi Yasukawa and Tadamitsu Kishimoto and Yuh Cheng Yang},
  journal={Journal of immunology},
  year={1993},
  volume={151 5},
  pages={2555-61}
}
IL-11 is a novel cytokine with a variety of biofunctions which overlap with those of IL-6. We have previously identified IL-11 specific binding protein which is distinct from that of IL-6 in a number of cell lines. The similarities in biofunctions and differences in ligand binding proteins between IL-11 and IL-6 prompted us to investigate whether IL-11 shares common signal transduction mechanisms with IL-6. We have examined early signals triggered by IL-11 or IL-6 in a multifactor-dependent… CONTINUE READING
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