Involvement of Hypoxia-Inducible Factor-1 in the Inflammatory Responses of Human LAD2 Mast Cells and Basophils

@inproceedings{Sumbayev2012InvolvementOH,
  title={Involvement of Hypoxia-Inducible Factor-1 in the Inflammatory Responses of Human LAD2 Mast Cells and Basophils},
  author={Vadim V. Sumbayev and Inna M. Yasinska and Abraham E. Oniku and Claire L. Streatfield and Bernhard F. Gibbs},
  booktitle={PloS one},
  year={2012}
}
We recently showed that hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the pro-allergic functions of human basophils by transcriptional control of energy metabolism via glycolysis as well as directly triggering expression of the angiogenic cytokine vascular endothelium growth factor (VEGF). Here, we investigated HIF-1 involvement in controlling the synthesis of angiogenic and inflammatory cytokines from various human effector cells stimulated by IgE-dependent or innate immune… CONTINUE READING
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