Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits.

@article{Naito2007InvolvementOH,
  title={Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits.},
  author={Tadasuke Naito and Fumitaka Momose and Atsushi Kawaguchi and Kyosuke Nagata},
  journal={Journal of virology},
  year={2007},
  volume={81 3},
  pages={1339-49}
}
Transcription and replication of the influenza virus RNA genome occur in the nuclei of infected cells through the viral RNA-dependent RNA polymerase consisting of PB1, PB2, and PA. We previously identified a host factor designated RAF-1 (RNA polymerase activating factor 1) that stimulates viral RNA synthesis. RAF-1 is found to be identical to Hsp90. Here, we examined the intracellular localization of Hsp90 and viral RNA polymerase subunits and their molecular interaction. Hsp90 was found to… CONTINUE READING

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