Involvement of Hat1p (Kat1p) catalytic activity and subcellular localization in telomeric silencing.


Previous studies have shown that loss of the type B histone acetyltransferase Hat1p leads to defects in telomeric silencing in Saccharomyces cerevisiae. We used this phenotype to explore a number of functional characteristics of this enzyme. To determine whether the enzymatic activity of Hat1p is necessary for its role in telomeric silencing, a structurally… (More)
DOI: 10.1074/jbc.M802564200


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