Involvement of HIV-1 protease in virus-induced cell killing.


Acute infection of human CD4+ cells with cytopathic strains of HIV-1 causes rapid cell death. The role played by HIV-1 protease (PR) in virus-induced cell killing was investigated by subjecting C8166 cells to a single round of infection. The presence of HIV-1 PR inhibitor saquinavir from 24h post-infection prevented virus-induced cell lysis. This inhibitor… (More)



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@article{Ventoso2005InvolvementOH, title={Involvement of HIV-1 protease in virus-induced cell killing.}, author={Iv{\'a}n Ventoso and Joaqu{\'i}n Moya Navarro and Mar{\'i}a {\'A}ngeles Mu{\~n}oz and L Roman Carrasco}, journal={Antiviral research}, year={2005}, volume={66 1}, pages={47-55} }