Involvement of H2-receptors in the mechanism of analgesic action of Tyr-MIF-1.

Abstract

The antinociceptive effects of H2-agents cimetidine (CIM) and dimaprit (DMP) as well as their effects on the Tyr-MIF-1-evoked analgesia have been studied after intraperitoneal (i.p.) administration in rats. In the paw-pressure (PP) test Tyr-MIF-1 (1 mg/kg), CIM (50 and 100mg/kg) and DMP (5 and 10mg/kg) induced analgesia. Injected before DMP, naloxone (NAL… (More)

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Cite this paper

@article{Zamfirova2003InvolvementOH, title={Involvement of H2-receptors in the mechanism of analgesic action of Tyr-MIF-1.}, author={Rossitsa Zamfirova and Adriana I. Bocheva and Simeon B. Todorov}, journal={Archives of physiology and biochemistry}, year={2003}, volume={111 5}, pages={443-7} }