Involvement of GR and p300 in the induction of H6PD by cortisol in human amnion fibroblasts.

Abstract

Human fetal membranes express 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which reduces biologically inert cortisone to active cortisol and may provide an extraadrenal source of cortisol mediating fetal development and parturition. The reductase activity of 11β-HSD1 depends on the availability of the cofactor reduced form of nicotinamide adenine… (More)
DOI: 10.1210/en.2012-1531

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