Involvement of GABAA receptors in the outgrowth of cultured hippocampal neurons

  title={Involvement of GABAA receptors in the outgrowth of cultured hippocampal neurons},
  author={Gilles Barbin and H{\'e}l{\`e}ne Pollard and J. L. Ga{\"i}arsa and Yezekiel Ben‐Ari},
  journal={Neuroscience Letters},

Figures and Tables from this paper

GABAA Receptors Mediate Trophic Effects of GABA on Embryonic Brainstem Monoamine Neurons In Vitro
Results demonstrate that the activation/inhibition of GABAA receptors produces opposite effects on the development of embryonic monoamine and GABA neurons, which suggests that these neurotransmitter phenotypes may express GabAAreceptors that differ in fundamental ways, and these differences determine the developmental responses of these cells to GABAergic stimuli.
Effects of GABA and GABA receptor inhibition on differentiation of mesencephalic precursors into dopaminergic neurons in vitro
The results suggest that effects are exerted via GABA receptors located on DA precursors, and are not an indirect consequence of effects on the serotonergic or glial cell population.
Postnatal maturation of gamma-aminobutyric acidA and B-mediated inhibition in the CA3 hippocampal region of the rat.
It is reported that GABA mediates most of the excitatory drive at early stages of development in the hippocampal CA3 region and plays a trophic role in the neuritic outgrowth of cultured hippocampal neurons.
Glutamate Inhibits GABA Excitatory Activity in Developing Neurons
The data suggest that in developing neurons glutamate can inhibit the excitatory actions of GABA at both presynaptic and postsynaptic sites, and this may be one set of mechanisms whereby the actions of two excitatories transmitters, GABA and glutamate, do not lead to runaway excitation in the developing brain.
GABAB Receptor Activation Triggers BDNF Release and Promotes the Maturation of GABAergic Synapses
A novel mechanism by which endogenous GABA selectively regulates the development of GABAergic synapses in the developing brain is demonstrated by using whole-cell patch-clamp recordings and time-lapse fluorescence imaging on cultured hippocampal neurons expressing GFP-tagged brain-derived neurotrophic factor.
GABAergic stimulation switches from enhancing to repressing BDNF expression in rat hippocampal neurons during maturation in vitro.
Observations support the hypothesis that GABA might have neurotrophic effects on embryonic or perinatal hippocampal neurons, which are mediated by BDNF.
GABA neurotransmission in the hypothalamus: developmental reversal from Ca2+ elevating to depressing
It is suggested that GABA elevates Ca2+ in developing, but not mature, neurons from the hypothalamus and all other brain regions examined, or whether it might exist throughout the brain.


Neurotrophic effects of GABA in cultures of embryonic chick brain and retina
The hypothesis that GABA functions as a trophic or regulatory factor of at least certain neuron types of embryonic chick cortical and retinal neurons in culture is supported.
Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons
  • M. Mattson, P. Dou, S. Kater
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1988
Results indicate that activation of glutamate receptors leads to the opening of voltage-dependent calcium channels; the resulting increases in calcium influx lead to the observed alterations in dendritic outgrowth and neuronal survival.
The trophic effect of gaba on cerebellar granule cells is mediated by gaba-receptors
Neurotransmitters in the regulation of neuronal cytoarchitecture
  • M. Mattson
  • Biology, Psychology
    Brain Research Reviews
  • 1988