Involvement of Fyn tyrosine kinase in progression of cytokinesis of B lymphocyte progenitor

@article{Yasunaga1996InvolvementOF,
  title={Involvement of Fyn tyrosine kinase in progression of cytokinesis of B lymphocyte progenitor},
  author={Masa Yasunaga and Takeshi Yagi and Naoto Hanzawa and Masako Yasuda and Yuji Yamanashi and Tetsuya Yamamoto and Shinichi Aizawa and Yoshiteru Miyauchi and Seiji Nishikawa},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={132},
  pages={91 - 99}
}
We analyzed the role of Fyn tyrosine kinase in cell cycle progression of B lymphocyte progenitor (pro B cell). Whereas there were no substantial defects in the intramarrow B cell genesis in the fyn(-) mouse, and long-term proliferation of fyn(-) pro B cells was maintained in vitro under a serum containing culture condition, the cell cycle was arrested at G2/M upon serum deprivation. Morphological analyses demonstrated that the cytokinesis of fyn(-) pro B cells was retarded in the presence of… CONTINUE READING

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