Involvement of FOXL2 and RSPO1 in Ovarian Determination, Development, and Maintenance in Mammals.

@article{Pannetier2016InvolvementOF,
  title={Involvement of FOXL2 and RSPO1 in Ovarian Determination, Development, and Maintenance in Mammals.},
  author={Ma{\"e}lle Pannetier and A. A. Chassot and Marie-Christine Chaboissier and Eric A. Pailhoux},
  journal={Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation},
  year={2016},
  volume={10 4},
  pages={167-184}
}
In mammals, sex determination is a process through which the gonad is committed to differentiate into a testis or an ovary. This process relies on a delicate balance between genetic pathways that promote one fate and inhibit the other. Once the gonad is committed to the female pathway, ovarian differentiation begins and, depending on the species, is completed during gestation or shortly after birth. During this step, granulosa cell precursors, steroidogenic cells, and primordial germ cells… CONTINUE READING