Involvement of Escherichia coli DNA polymerase IV in tolerance of cytotoxic alkylating DNA lesions in vivo.

@article{Bjedov2007InvolvementOE,
  title={Involvement of Escherichia coli DNA polymerase IV in tolerance of cytotoxic alkylating DNA lesions in vivo.},
  author={Ivana Bjedov and Chitralekha Nag Dasgupta and Dea Slade and Sophie Le Blastier and Marjorie Selva and Ivan Matic},
  journal={Genetics},
  year={2007},
  volume={176 3},
  pages={1431-40}
}
Escherichia coli PolIV, a DNA polymerase capable of catalyzing synthesis past replication-blocking DNA lesions, belongs to the most ubiquitous branch of Y-family DNA polymerases. The goal of this study is to identify spontaneous DNA damage that is bypassed specifically and accurately by PolIV in vivo. We increased the amount of spontaneous DNA lesions using mutants deficient for different DNA repair pathways and measured mutation frequency in PolIV-proficient and -deficient backgrounds. We… CONTINUE READING

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