Corpus ID: 91364258

Involvement of Endothelial Nitric Oxide in Sphingosine-1-Phosphate–Induced Angiogenesis

  title={Involvement of Endothelial Nitric Oxide in Sphingosine-1-Phosphate–Induced Angiogenesis},
  author={YoshiyukiRikitake and Ken-ichiHirata and SeinosukeKawashima and Masanoriozaki and TomosaburoTakahashi and WataruOgawa and NobutakaInoue and MitsuhiroYokoyama},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology},
Nitric oxide (NO) has been implicated as a critical signaling molecule of angiogenesis. Recently, sphingosine-1-phosphate (S1P) has emerged as a mediator of angiogenesis, and S1P-induced NO synthesis in endothelial cells (ECs) has been reported. To analyze the signaling pathways involved in S1P-induced angiogenesis and clarify the role of NO in this process, we performed in vivo and in vitro angiogenesis assays. S1P activated the phosphatidylinositol-3-kinase (PI3K)/Akt/endothelial NO synthase… Expand
28 Citations
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  • 113
  • PDF
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  • 64
  • PDF
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  • 32
  • PDF
The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation.
  • 321
  • PDF
Therapeutic angiogenesis: new indication for endothelial NO synthase gene transfer.
  • Z. Katušić
  • Biology, Medicine
  • Arteriosclerosis, thrombosis, and vascular biology
  • 2002
  • 9
Nitric oxide and sphingolipids: mechanisms of interaction and role in cellular pathophysiology
  • 25