Involvement of ERK1/2 in invasiveness and metastatic development of rat prostatic adenocarcinoma.

Abstract

Extracellular signal-regulated kinase (ERK) activation has been implicated in cell motility and invasion. In this study, we demonstrated that the steady-state levels of activated ERK1/2 correlated with the degree of invasiveness and metastatic potential of three Dunning cancer cell lines, originating from the same parental tumor. Inhibition of mitogen… (More)

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