Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists.
@article{Ribeiro2013InvolvementOE, title={Involvement of ERK1/2, cPLA2 and NF-$\kappa$B in microglia suppression by cannabinoid receptor agonists and antagonists.}, author={Rachel Ribeiro and Jie Wen and Shihe Li and Yumin Zhang}, journal={Prostaglandins \& other lipid mediators}, year={2013}, volume={100-101}, pages={ 1-14 } }
43 Citations
Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer’s disease and levodopa-induced dyskinesia
- Biology, ChemistryBrain, Behavior, and Immunity
- 2018
Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway
- Biology, MedicineJournal of Neuroinflammation
- 2015
The results in this study demonstrated the role of cPLA2 in microglial activation with metabolic links to oxidative and inflammatory responses, and this was in part regulated by the AA metabolic pathways, namely the LOXs.
CB2 Receptor Activation Ameliorates the Proinflammatory Activity in Acute Lung Injury Induced by Paraquat
- Biology, MedicineBioMed research international
- 2014
It is suggested that activating CB2 receptor exerted protective activity against PQ-induced ALI, and it potentially contributed to the suppression of the activation of MAPKs and NF-κB pathways.
Anti-Inflammatory Effects by Pharmacological Inhibition or Knockdown of Fatty Acid Amide Hydrolase in BV2 Microglial Cells
- Biology, ChemistryCells
- 2019
Although inhibition and knockdown of FAAH have potent anti-inflammatory effects and possibly lead to the dynamic change of microglial gene regulation, the underlying mechanisms remain to be elucidated.
Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent
- Biology, MedicineBreast cancer
- 2016
The results of this work characterize the actions of a CB2-selective agonist on breast cancer cells in a syngeneic murine model representing how a clinical presentation of cancer progression and metastasis may be significantly modulated by a G-protein-coupled receptor.
Non‐psychotropic Cannabis sativa L. phytocomplex modulates microglial inflammatory response through CB2 receptors‐, endocannabinoids‐, and NF‐κB‐mediated signaling
- BiologyPhytotherapy research : PTR
- 2022
The data suggest that C. sativa phytocomplex and its multitarget mechanism could represent a novel therapeutic strategy for neuroinflammatory‐related diseases.
Inflammation and Nitro-oxidative Stress as Drivers of Endocannabinoid System Aberrations in Mood Disorders and Schizophrenia
- BiologyMolecular Neurobiology
- 2022
It is suggested that cannabidiol and dimethyl fumarate may have therapeutic potential for major depressive disorder, bipolar disorder and schizophrenia.
Therapeutic potential of a novel cannabinoid agent CB52 in the mouse model of experimental autoimmune encephalomyelitis
- Biology, ChemistryNeuroscience
- 2013
Role of G Protein-Coupled Receptors in Microglial Activation: Implication in Parkinson’s Disease
- Biology, ChemistryFrontiers in Aging Neuroscience
- 2021
The implication of microglial GPCRs-regulated neuroinflammation to the pathophysiology of PD and their potential to become a new expectation for clinical therapeutics are expounded.
Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189.
- Biology, ChemistryBioorganic & medicinal chemistry
- 2021
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