Involvement of ERK-Nrf-2 Signaling in Ionizing Radiation Induced Cell Death in Normal and Tumor Cells

@inproceedings{Patwardhan2013InvolvementOE,
  title={Involvement of ERK-Nrf-2 Signaling in Ionizing Radiation Induced Cell Death in Normal and Tumor Cells},
  author={Raghavendra S. Patwardhan and Rahul Checker and Deepak Sharma and Santosh Kumar Sandur and Krishna Balaji Sainis},
  booktitle={PloS one},
  year={2013}
}
Prolonged oxidative stress favors tumorigenic environment and inflammation. Oxidative stress may trigger redox adaptation mechanism(s) in tumor cells but not normal cells. This may increase levels of intracellular antioxidants and establish a new redox homeostasis. Nrf-2, a master regulator of battery of antioxidant genes is constitutively activated in many tumor cells. Here we show that, murine T cell lymphoma EL-4 cells show constitutive and inducible radioresistance via activation of Nrf-2… CONTINUE READING

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