Involvement of ERK 1/2 activation in electroacupuncture pretreatment via cannabinoid CB1 receptor in rats.

@article{Du2010InvolvementOE,
  title={Involvement of ERK 1/2 activation in electroacupuncture pretreatment via cannabinoid CB1 receptor in rats.},
  author={Juan Du and Qiang Wang and Bo Hu and Zheng-wu Peng and Yu Zhao and Lei Ma and Lize Xiong and Yan Lu and Xiaoling Zhu and Shaoyang Chen},
  journal={Brain research},
  year={2010},
  volume={1360},
  pages={1-7}
}
Our previous study demonstrated that pretreatment with electroacupuncture (EA) elicited protective effects against transient cerebral ischemia through cannabinoid receptor type 1 receptor (CB1R). In the present study, we investigated whether or not the extracellular signal regulated-kinase 1/2 (ERK1/2) pathway was involved in the ischemic tolerance induced by EA pretreatment through CB1R. At 24h after the end of the last EA pretreatment, focal cerebral ischemia was induced by middle cerebral… CONTINUE READING