Involvement of E-cadherin and beta-catenin in germ cell tumours and in normal male fetal germ cell development.

@article{Honecker2004InvolvementOE,
  title={Involvement of E-cadherin and beta-catenin in germ cell tumours and in normal male fetal germ cell development.},
  author={Friedemann Honecker and A. M. Kersemaekers and Michel Molier and Pascale C. van Weeren and Hans Stoop and Ronald R. de Krijger and Katja Pollina Wolffenbuttel and Wolter Oosterhuis and C Carsten Bokemeyer and Leendert H J Looijenga},
  journal={The Journal of pathology},
  year={2004},
  volume={204 2},
  pages={167-74}
}
Intercellular contacts, mediated by E-cadherin, are essential for germ cell migration and maturation. Furthermore, it has been suggested that decrease or loss of E-cadherin correlates with tumour progression and invasive behaviour. beta-catenin is involved in a number of different processes, including cell--cell interaction when bound to cadherins, and determination of cell fate in pluripotent cells when activated via the Wnt signal-transduction pathway. To shed more light on the role of these… CONTINUE READING

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