Involvement of E-cadherin, beta-catenin, Cdc42 and CXCR4 in the progression and prognosis of cutaneous melanoma.

@article{Tucci2007InvolvementOE,
  title={Involvement of E-cadherin, beta-catenin, Cdc42 and CXCR4 in the progression and prognosis of cutaneous melanoma.},
  author={Maria Giovanna Tucci and Guendalina Lucarini and Donatella Brancorsini and Antonio Zizzi and Armanda Pugnaloni and Alfredo Giacchetti and Giuseppe Ricotti and G. Biagini},
  journal={The British journal of dermatology},
  year={2007},
  volume={157 6},
  pages={1212-6}
}
BACKGROUND A key event in cancer metastasis is the migration of tumour cells from their original location to a secondary site. The development of melanoma may be viewed as a consequence of the disruption of homeostatic mechanisms in the skin of the original site. OBJECTIVES To investigate whether dysregulation of cell motility (Cdc42 expression), escaping the control of cell-cell and cell-matrix interactions (E-cadherin, beta-catenin expression), enhances melanoma progression, and whether… CONTINUE READING

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