Involvement of DNase gamma in apoptosis associated with myogenic differentiation of C2C12 cells.

@article{Shiokawa2002InvolvementOD,
  title={Involvement of DNase gamma in apoptosis associated with myogenic differentiation of C2C12 cells.},
  author={Daisuke Shiokawa and Takanobu Kobayashi and Sei-ichi Tanuma},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 34},
  pages={31031-7}
}
Nucleosomal DNA fragmentation is detected in myoblasts only when apoptosis is induced under differentiating conditions. However, the molecular mechanisms and the DNase responsible for the differentiation-dependent apoptotic DNA laddering are poorly understood. Here we show that a Ca(2+)/Mg(2+)-dependent endonuclease, DNase gamma, is induced in C2C12 myoblasts during myogenic differentiation and catalyzes apoptotic DNA fragmentation in differentiating myoblasts. A Ca(2+)/Mg(2+)-dependent, Zn(2… CONTINUE READING
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