Involvement of DNMT 3B promotes epithelial-mesenchymal transition and gene expression profile of invasive head and neck squamous cell carcinomas cell lines.

@article{Chen2016InvolvementOD,
  title={Involvement of DNMT 3B promotes epithelial-mesenchymal transition and gene expression profile of invasive head and neck squamous cell carcinomas cell lines.},
  author={Li-Hsuen Chen and W-B. Hsu and Yen-Ju Tseng and Di Christina Liu and Ching-Feng Weng},
  journal={BMC cancer},
  year={2016},
  volume={16},
  pages={
          431
        }
}
BACKGROUND The 5-year overall survival rates for head and neck cancer (HNC) relies on distant metastasis. Importantly, the epithelial-mesenchymal transition (EMT) is believed to be an initial step of metastasis. However, the relationship of epigenetic with EMT formation is still unexplored in HNC. This study focuses on invasive subclones of HNC cell lines through the simulation of invasion in vitro; and underlying mechanisms were analyzed including DNA methylation and gene expression profile… CONTINUE READING
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