Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles.

@article{Forgues2003InvolvementOC,
  title={Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles.},
  author={Marshonna Forgues and Michael J. Difilippantonio and Steven P. Linke and Thomas Ried and Kunio Nagashima and Jeffrey P. Feden and Kristoffer Valerie and Kenji Fukasawa and Xin Wei Wang},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 15},
  pages={5282-92}
}
Hepatitis B virus (HBV) includes an X gene (HBx gene) that plays a critical role in liver carcinogenesis. Because centrosome abnormalities are associated with genomic instability in most human cancer cells, we examined the effect of HBx on centrosomes. We found that HBx induced supernumerary centrosomes and multipolar spindles. This effect was independent… CONTINUE READING