Involvement of Central Cholinergic Mechanisms in the Effects of Oxytocin and an Oxytocin Receptor Antagonist on Retention Performance in Mice

@article{Boccia2000InvolvementOC,
  title={Involvement of Central Cholinergic Mechanisms in the Effects of Oxytocin and an Oxytocin Receptor Antagonist on Retention Performance in Mice},
  author={Mariano M. Boccia and Carlos Mar{\'i}a Baratti},
  journal={Neurobiology of Learning and Memory},
  year={2000},
  volume={74},
  pages={217-228}
}
  • M. Boccia, C. Baratti
  • Published 1 November 2000
  • Biology, Psychology, Medicine
  • Neurobiology of Learning and Memory
Oxytocin (OT, 0.10 microg/kg, sc) impaired retention of a one-trial step-through inhibitory avoidance task when injected into male Swiss mice 10 min after training, as indicated by retention performance 48 h later. In contrast, the immediate post-training administration of the putative oxytocin receptor antagonist d(CH(2))(5)[Tyr(Me)(2), Thr(4), Thy-NH(9)(2)] OVT (AOT, 0.30 microg/kg, sc) significantly enhanced retention performance. Neither OT nor AOT affected response latencies in mice not… 

Figures and Tables from this paper

Posttrial Administration of Cholinergic Drugs does not Affect Consummatory Successive Negative Contrast in Rats

TLDR
The results indicate that atropine and physostigmine have no effects on contrast, and the role of cholinergic neurotransmission in the memory of surprising reward changes is discussed.

References

SHOWING 1-10 OF 72 REFERENCES

Effects of oxytocin and an oxytocin receptor antagonist on retention of a nose-poke habituation response in mice.

  • M. BocciaC. Baratti
  • Biology, Psychology
    Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia
  • 1999
TLDR
It is suggested that nose-poke habituation learning can be a suitable method to investigate the mnestic effects of drugs, and that oxytocin negatively modulates memory storage of this form of learning elicited by stimuli repeatedly presented without reinforcement.

Effects of oxytocin and an oxytocin receptor antagonist on retention of a nose-poke habituation response in mice.

TLDR
It is suggested that nose-poke habituation learning can be a suitable method to investigate the mnestic effects of drugs, and that oxytocin negatively modulates memory storage of this form of learning elicited by stimuli repeatedly presented without reinforcement.

Memory-improving actions of glucose: involvement of a central cholinergic muscarinic mechanism.

The Post-training Memory Enhancement Induced by Physostigmine and Oxotremorine in Mice Is Not State-Dependent

TLDR
Findings indicate that the memory-enhancing effects of post-training administration of physostigmine or OTM are not state-dependent and are consistent with the view that the behavioral effects of the cholinomimetics drugs are mediated through an interaction with the neural processes underlying the storage of acquired information.

The enhancement of retention performance induced by picrotoxin in mice may be mediated through a release of endogenous vasopressin

TLDR
The findings suggest that the better retention performance induced by post-training administration of picrotoxin could result, at least in part, from an endogenous release of vasopressin.
...