Involvement of Central Cholinergic Mechanisms in the Effects of Oxytocin and an Oxytocin Receptor Antagonist on Retention Performance in Mice

@article{Boccia2000InvolvementOC,
  title={Involvement of Central Cholinergic Mechanisms in the Effects of Oxytocin and an Oxytocin Receptor Antagonist on Retention Performance in Mice},
  author={Mariano M. Boccia and Carlos Mar{\'i}a Baratti},
  journal={Neurobiology of Learning and Memory},
  year={2000},
  volume={74},
  pages={217-228}
}
Oxytocin (OT, 0.10 microg/kg, sc) impaired retention of a one-trial step-through inhibitory avoidance task when injected into male Swiss mice 10 min after training, as indicated by retention performance 48 h later. In contrast, the immediate post-training administration of the putative oxytocin receptor antagonist d(CH(2))(5)[Tyr(Me)(2), Thr(4), Thy-NH(9)(2)] OVT (AOT, 0.30 microg/kg, sc) significantly enhanced retention performance. Neither OT nor AOT affected response latencies in mice not… Expand
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References

SHOWING 1-10 OF 72 REFERENCES
Effects of oxytocin and an oxytocin receptor antagonist on retention of a nose-poke habituation response in mice.
  • M. Boccia, C. Baratti
  • Medicine
  • Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia
  • 1999
TLDR
It is suggested that nose-poke habituation learning can be a suitable method to investigate the mnestic effects of drugs, and that oxytocin negatively modulates memory storage of this form of learning elicited by stimuli repeatedly presented without reinforcement. Expand
Effects of oxytocin and an oxytocin receptor antagonist on retention of a nose-poke habituation response in mice.
The present study describes the use of nose-poke habituation as a memory task in mice and demonstrates that it is sensitive to oxytocin (OT) and an oxytocin receptor antagonist (AOT) administeredExpand
Effects of a Single Administration of Oxytocin or Vasopressin and Their Interactions with Two Selective Receptor Antagonists on Memory Storage in Mice
TLDR
The findings suggest that the impairment of retention of an inhibitory avoidance response in mice induced by posttraining oxytocin is probably due to an interaction of the neuropeptide with specific receptors. Expand
The enhancement of retention induced by vasopressin in mice may be mediated by an activation of central nicotinic cholinergic mechanisms.
TLDR
The results suggest that the enhancement of retention induced by vasopressin is probably due to an activation of central nicotinic cholinergic mechanisms which are critical for memory formation. Expand
Possible interaction between central cholinergic muscarinic and opioid peptidergic systems during memory consolidation in mice.
TLDR
The results suggest that naloxone facilitated retention as a function of its opiate antagonist properties, and an inhibitory modulatory role for endogenous opioid systems on the activity of central cholinergic muscarinic systems during memory consolidation is suggested. Expand
Memory-modulatory effects of centrally acting noradrenergic drugs: possible involvement of brain cholinergic mechanisms.
TLDR
Findings are consistent with the view that brain muscarinic cholinergic mechanisms are involved in both the facilitatory and impairing effect of post-training clenbuterol on the modulation of memory storage. Expand
Memory-improving actions of glucose: involvement of a central cholinergic muscarinic mechanism.
TLDR
The findings suggest that the memory facilitation induced by post-training administration of glucose could result from an enhancement of brain acetylcholine synthesis and/or its release that, in turn, might modulate the activity of muscarinic cholinergic mechanisms that are critically involved in memory storage. Expand
The Post-training Memory Enhancement Induced by Physostigmine and Oxotremorine in Mice Is Not State-Dependent
TLDR
Findings indicate that the memory-enhancing effects of post-training administration of physostigmine or OTM are not state-dependent and are consistent with the view that the behavioral effects of the cholinomimetics drugs are mediated through an interaction with the neural processes underlying the storage of acquired information. Expand
The enhancement of retention performance induced by picrotoxin in mice may be mediated through a release of endogenous vasopressin
TLDR
The findings suggest that the better retention performance induced by post-training administration of picrotoxin could result, at least in part, from an endogenous release of vasopressin. Expand
Facilitation of memory storage by the acetylcholine M2 muscarinic receptor antagonist AF-DX 116.
TLDR
Findings suggest that the activation of a muscarinic cholinergic presynaptic inhibitory mechanism, probably by increasing brain acetylcholine release, may modulate the activity of post-training processes involved in memory storage. Expand
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