Involvement of Ca2+ sensitization in ropivacaine-induced contraction of rat aortic smooth muscle.

@article{Yu2005InvolvementOC,
  title={Involvement of Ca2+ sensitization in ropivacaine-induced contraction of rat aortic smooth muscle.},
  author={Jingui Yu and Yasuyuki Tokinaga and Toshiyuki Kuriyama and Nobuhiko Uematsu and Kazuhiro Mizumoto and Yoshio Hatano},
  journal={Anesthesiology},
  year={2005},
  volume={103 3},
  pages={548-55}
}
BACKGROUND The mechanisms of amino-amide local anesthetic agent-induced vasoconstriction remain unclear. The current study was designed to examine the roles of the protein kinase C (PKC), Rho kinase, and p44/42 mitogen-activated protein kinase (p44/42 MAPK) signaling pathways in calcium (Ca2+)-sensitization mechanisms in ropivacaine-induced vascular contraction. METHODS Endothelium-denuded rat aortic rings, segments, and strips were prepared. The cumulative dose-response relations of… CONTINUE READING
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