Involvement of Ca2+ release and activation of phospholipase A2 in mitochondrial dysfunction during anoxia.

@article{Nishida1989InvolvementOC,
  title={Involvement of Ca2+ release and activation of phospholipase A2 in mitochondrial dysfunction during anoxia.},
  author={Takeo Nishida and Toru Inoue and W Kamiike and Yoshiaki Kawashima and Kazuhiko Tagawa},
  journal={Journal of biochemistry},
  year={1989},
  volume={106 3},
  pages={533-8}
}
During anoxic incubation, depletion of mitochondrial ATP was followed by release of Ca2+ with concomitant increase in the rate of state 4 respiration due to disruption of the diffusion barrier against protons. The external addition of ATP and its non-metabolizable analog, beta,gamma-methylene adenosine 5'-triphosphate, prevented both the release of Ca2+ and increase in the rate of state 4 respiration. Addition of EGTA, which did not prevent release of the ion, resulted in little increase in the… CONTINUE READING