• Corpus ID: 23648814

Involvement of Ca2+ in dopamine release in striatal rat slices by PF9601N and L-deprenyl.

@article{Prez2000InvolvementOC,
  title={Involvement of Ca2+ in dopamine release in striatal rat slices by PF9601N and L-deprenyl.},
  author={Virgili P{\'e}rez and M Past{\'o} and Mercedes Unzeta},
  journal={Neurobiology},
  year={2000},
  volume={8 3-4},
  pages={
          237-42
        }
}
Rat striatal slices were incubated 1 hour in Krebs buffer with carbogen by continuous perfusion. When both MAO-B inhibitors PF9601N and l-deprenyl were added in the incubation medium, at 200 microM concentration, a diminution in the dopamine content was observed. The decrease in dopamine content was partially calcium dependent and showed a different mechanism between both compounds. When 1 mM concentration EGTA was added at the Krebs incubation medium without calcium, dopamine content was… 

Effects of monoamine oxidase inhibitors on cocaine discrimination in rats

TLDR
It is suggested that monoamine oxidase inhibitors can modulate the discriminative stimulus effects of cocaine for at least 24 h, and may be useful for treatment of cocaine abuse.