Involvement of CYP2D6 in oxidative metabolism of cinnarizine and flunarizine in human liver microsomes.

Abstract

Oxidative metabolism of cinnarizine (CZ) and its fluorine derivative flunarizine (FZ), both of which are selective calcium entry blockers, was examined in human liver microsomes. The ring-hydroxylations and the N-desalkylations constituted primary metabolic pathways in microsomal metabolism of CZ and FZ. Among these pathways, the ring-hydroxylase (p… (More)

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Cite this paper

@article{Narimatsu1993InvolvementOC, title={Involvement of CYP2D6 in oxidative metabolism of cinnarizine and flunarizine in human liver microsomes.}, author={Shizuo Narimatsu and Satoru Kariya and Shuji Isozaki and Shigeru Ohmori and Mitsukazu Kitada and Seijiro Hosokawa and Yasuhiro Masubuchi and T Suzuki}, journal={Biochemical and biophysical research communications}, year={1993}, volume={193 3}, pages={1262-8} }