Involvement of CYP2A6 in the formation of a novel metabolite, 3-hydroxypilocarpine, from pilocarpine in human liver microsomes.

@article{Endo2007InvolvementOC,
  title={Involvement of CYP2A6 in the formation of a novel metabolite, 3-hydroxypilocarpine, from pilocarpine in human liver microsomes.},
  author={Takuro Endo and Masaaki Ban and Kazuma Hirata and Akitoshi Yamamoto and Yoshiki Hara and Yasunori Momose},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2007},
  volume={35 3},
  pages={476-83}
}
Pilocarpine is a cholinergic agonist that is metabolized to pilocarpic acid by serum esterase. In this study, we discovered a novel metabolite in human urine after the oral administration of pilocarpine hydrochloride, and we investigated the metabolic enzyme responsible for the metabolite formation. The structure of the metabolite was identified as 3… CONTINUE READING