Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis.

  title={Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis.},
  author={J. Hasegawa and Shinji Kamada and Wataru Kamiike and Saori Shimizu and Tetsuo Imazu and Hiroshi Matsuda and Yoshihide Tsujimoto},
  journal={Cancer research},
  volume={56 8},
Fas (Apo-1/CD95) belongs to the tumor necrosis factor/nerve growth factor receptor family and transmits apoptotic signals by binding to its ligand. Interleukin-1beta-converting enzyme (ICE), which shows substantial homology to the product of the cell death gene, ced-3, of Caenorhabditis elegans, is reported to be involved in Fas-mediated apoptosis. Using two human carcinoma-derived cell lines with undetectable levels of ICE, we found that an agonistic antihuman Fas antibody induces the… CONTINUE READING


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