Involvement of CGRP in the inhibitory effect of rutaecarpine on vasoconstriction induced by anaphylaxis in guinea pig

@article{Yu2005InvolvementOC,
  title={Involvement of CGRP in the inhibitory effect of rutaecarpine on vasoconstriction induced by anaphylaxis in guinea pig},
  author={Jing Yu and Guishan Tan and Pan-Yue Deng and Kang-ping Xu and Chang-Ping Hu and Yuan‐jian Li},
  journal={Regulatory Peptides},
  year={2005},
  volume={125},
  pages={93-97}
}

Involvement of TRPV1 in the expression and release of calcitonin gene-related peptide induced by rutaecarpine

It was concluded that TRPV1 was involved in the expression and release of CGRP stimulated by rutaecarpine, which provided novel mechanistic understanding of the treatment of hypertension using the Chinese herb Wu-Chu-Yu.

Rutaecarpine Induces Chloride Secretion across Rat Isolated Distal Colon

The evidence derived from present study suggests that Rut-stimulated Cl– secretion is mediated by generation of endogenous prostaglandin E2 and that it also involves the stimulation of cAMP and protein kinase A pathways, which subsequently lead to the activation of apical Cl– channels, mostly the CFTR and basolateral cAMP-dependent K+ channels.

INVOLVEMENT OF PROLYLCARBOXYPEPTIDASE IN THE EFFECT OF RUTAECARPINE ON THE REGRESSION OF MESENTERIC ARTERY HYPERTROPHY IN RENOVASCULAR HYPERTENSIVE RATS

The data suggest that the repression of increases in systolic blood pressure and reversal of mesenteric artery remodelling by rutaecarpine may be related to increased expression of PRCP in the circulation and small arteries in 2K1C hypertensive rats.

The protective effects of rutaecarpine on acute pancreatitis.

It is indicated that rutaecarpine protects against AP in rats by upregulating endogenous CGRP release via activation VR1 of, to improving the microcirculation of the pancreatic tissue and regulate the expression of inflammatory factors.

Low-Cytotoxic Synthetic Bromorutaecarpine Exhibits Anti-Inflammation and Activation of Transient Receptor Potential Vanilloid Type 1 Activities

The designed and synthesized a derivative of RUT, bromo-dimethoxyrutaecarpine (Br-RUT), which showed no cytotoxicity at 20 μM and retains its activities against inflammation and vasodilation that could be beneficial for cardiovascular disease therapeutics.

Solid dispersion of rutaecarpine improved its antihypertensive effect in spontaneously hypertensive rats

A change of the dosage from the crude drug to solid dispersion could improve significantly the efficiency of rutaecarpine absorption and increase its plasma concentration, and the anti‐hypertensive effect exerted by rutaECarpine solid disp immersion in SHR is mediated by CGRP.

Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4‐ROS‐ADAM17 pathway

In vitro experiments confirmed the results of in vitro experiments that rutaecarpine significantly inhibited Ang II‐induced cardiac hypertrophy in primary cardiomyocytes and suppressed the Nox4‐ROS‐ADAM17 pathway and over‐activation of extracellular signal‐regulated kinase (ERK) 1/2 pathway in the left ventricle of AAC‐induced hypertensive rats and primary carduomyocytes stimulated with Ang II.

Pellitorine, an extract of Tetradium daniellii, is an antagonist of the ion channel TRPV1.

  • Z. OláhD. Rédei J. Hohmann
  • Biology, Chemistry
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2017

Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components

Stimulation of calcitonin gene-related peptide release may partially explain the analgesic, cardiovascular and gastrointestinal protective, anti-obese activities of Evodia rutaecarpa and its major bioactive components.

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Protective effects of calcitonin gene-related peptide-mediated evodiamine on guinea-pig cardiac anaphylaxis

The results suggest that evodiamine possesses a protective effect of cardiac anaphylactic injury and that the effect of evodia rutaecarpa Bentham (Rutaceae) is related to stimulation of CGRP release.

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The results suggested that Rut lowered blood pressure by mainly activating the endothelial Ca2+-nitric oxide-cGMP pathway to reduce smooth muscle tone.

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It is concluded that leukotrienes have a major role in guinea‐pig cardiac anaphylaxis, and that CGS 8515 has a cardio‐protective action.

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