Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1

@article{Zhou2004InvolvementOC,
  title={Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1},
  author={Jun Gang Zhou and Ping Zhu and Jian-li Jiang and Qing Zhang and Zhen Biao Wu and Xi Ying Yao and Hao Tang and Ning Lu and Yong Yang and Zhi-Nan Chen},
  journal={BMC Cell Biology},
  year={2004},
  volume={6},
  pages={25 - 25}
}
During infection and inflammation, circulating blood monocytes migrate from the intravascular compartments to the extravascular compartments, where they mature into tissue macrophages. The maturation process prepares the cells to actively participate in the inflammatory and immune responses, and many factors have been reported to be involved in the process. We found in our study that CD147 played a very important role in this process. By using PMA-differentiated human monocyte cells line THP-1… CONTINUE READING

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